J Interdiscip Dentistry
Home | About JID | Editors | Search | Ahead of print | Current Issue | Archives | Instructions |
Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 256  | Login  | Contact us | Advertise | Subscribe  
ORIGINAL ARTICLE
Year : 2012  |  Volume : 2  |  Issue : 1  |  Page : 25-29

Immunolocalization of c-Fos, c-Jun and Fra-2 in healthy human marginal gingival tissues


Department of Histology and Embryology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey

Correspondence Address:
Nurullah Keklikoglu
Department of Histology and Embryology, Faculty of Dentistry, Istanbul University, Istanbul
Turkey
Login to access the Email id

Source of Support: The Research Fund of the Istanbul University (Project number: BYP-762/23082005)., Conflict of Interest: None


DOI: 10.4103/2229-5194.94188

Rights and Permissions

Background and Objective: Keeping marginal gingiva healthy is possible with some cellular processes. Activator Protein-1 (AP-1) members Fos and Jun proteins regulate cellular processes including growth, proliferation, differentiation and apoptosis. The aim of this study was to compare of immunoreactivity (IR) of some same or different family member AP-1 proteins in cells forming marginal gingival mucosa. Materials and Methods: IR of Fos family members c-Fos (c-Fos-IR) and Fra-2 (Fra-2-IR) and Jun family member c-Jun (c-Jun-IR) were analysed in epithelial cells (ECs) and lamina propria cells (LPCs) of healthy human marginal gingiva by immunohistochemical method. Results: Both in ECs and LPCs, c-Fos-IR positivity was found higher than the others and Fra-2-IR positivity was found lower. The most postivity was observed in c-Fos-IR in ECs and the least IR was observed in Fra-2-IR in LPCs. Furthermore, the IR positivity percentage of all proteins was found higher in ECs than in LPCs. In the comparision of each of c-Fos-IR, c-Jun-IR and Fra-2-IR in ECs and LPCs, no statistically significant difference in c-Jun-IR was observed; however, there were statistically significant differences in c-Fos-IR and Fra-2-IR. Conclusions: According to these findings, it can be proposed that c-Fos protein in healthy gingiva is more related with physiological processes than other proteins. In this study, establishing a statistically significant difference between c-Fos-IR and Fra-2-IR in both ECs and LPCs has shown that as well as these proteins are within the same family, each one may be related with different cellular processes.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1851    
    Printed103    
    Emailed0    
    PDF Downloaded239    
    Comments [Add]    

Recommend this journal